The Herzenberg Laboratory
HIV/Redox Group
| Len & Lee Herzenberg |
| Publications |
| B-Cell Group |
| HIV/Redox Group |
| FACS Development Group |
| Carbohydrate Microarray Group |
| Technicians |
| Administration |
| Contact Info and Directions |
| Former LAH Associates |
| Links |
| Research |
| The Herzenberg work on HIV and Redox is primarily focusing on Glutathione (GSH) and the effects of N'Acetylcysteine (NAC). In vitro studies showing that low GSH levels both promote HIV expression and impair T cell function suggest a link between GSH depletion and HIV disease progression. Oral administration of the GSH prodrug N-acetylcysteine (NAC) replenishes GSH in these subjects. Survival studies have shown GSH deficiency to be a key determinant of survival in AIDS.
CD11b (Mac-1, CR3), a member of the beta-intergin family of adhesion proteins is expressed in very low levels on the surface of unstimulated neutrophils but is primarily stored in secretory granuaes within the cell. We are attempting to determine whether neutrophil surface expression of CD11b predict early-onset infection or suspected infections. We have completed a preliminary study in neonates and have published our findings. Other human studies focus on multiparameter FACS analysis of T cell subsets. We are currently using up to 11-color FACS to study changes in dozens of lymphocyte subsets (e.g., naive and memory subsets of alphabeta and gammadelta T cells) in control adults and children, as well as, adults and children with diseases such as HIV, HBC and HCV infections. |
|
|
|
